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In summary, by integrating high-content single-cell level imaging analyses with mechanistic studies, extensive preclinical therapeutic experiments and a Phase Ib clinical trial, our studies herein elucidate the AR +/- BCL-2 +/- PCa cell subpopulation dynamics and credentials BCL-2 as a vital therapeutic target in heterogeneous CRPC

As we grow older, or when we are exposed to too much stress and environmental pollution (which is a daily reality for most Indians living in cities), the body's natural glutathione levels start to fall